{"id":82640,"date":"2025-08-05T11:07:17","date_gmt":"2025-08-05T19:07:17","guid":{"rendered":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/2025\/08\/05\/microdosing-lsd-can-help-treat-separation-anxiety-in-dogs-new-case-study-suggests\/"},"modified":"2025-08-06T20:04:22","modified_gmt":"2025-08-07T04:04:22","slug":"microdosing-lsd-can-help-treat-separation-anxiety-in-dogs-new-case-study-suggests","status":"publish","type":"post","link":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/2025\/08\/05\/microdosing-lsd-can-help-treat-separation-anxiety-in-dogs-new-case-study-suggests\/","title":{"rendered":"Microdosing LSD Can Help Treat Separation Anxiety In Dogs, New Case Study Suggests"},"content":{"rendered":"<\/p>\n

A new case study in the journal Veterinary Medicine and Science suggests that very small doses of the psychedelic LSD appeared to ease a dog\u2019s severe separation anxiety<\/a>, reducing destructive behavior and shortening the duration of vocalizations.<\/p>\n

Authors of the report said the results \u201csuggest potential therapeutic efficacy of microdosing 1cp-LSD in managing canine anxiety,\u201d though they acknowledged that future research is needed to validate the findings. They point out that anxiety is \u201cprevalent in dogs, affecting an estimated one-fifth of the canine population.\u201d<\/p>\n

The subject of the new study was a 13-year-old female dog of mixed breed, whom researchers had previously administered a single microdose of 1cP-LSD\u2014a semi-synthetic analogue of LSD with very similar psychoactive effects\u2014\u201dto observe the effects of the drug in the canine species, as no literature existed on this matter,\u201d the paper says.<\/p>\n

Results of the earlier experiment indicated the drug was \u201csafe and effectively reduced anxiety in the animal,\u201d authors wrote.<\/p>\n

The current study evaluated the dog\u2019s separation anxiety and how it changed over the course of a monthlong LSD treatment regimen. Using a points-based scale, researchers said the dog\u2019s \u201canxiety score significantly decreased from 29 (severe) to 14 (moderate) after treatment.\u201d<\/p>\n

\u201cA reduction in anxiety levels was observed, characterized by decreased destructive behaviour and shorter durations of vocalization,\u201d authors wrote. \u201cThis improvement was sustained 1 month following treatment, although vocalization frequency increased.\u201d<\/p>\n

Treatment consisted of administering 5 micrograms of 1cP-LSD\u2014or about 0.38 nanograms per kilogram of body weight\u2014orally to the dog every three days, which amounted to 10 total doses over the course of the month. \u201cThe substance was administered by disguising it in a piece of ham and delivered orally to the animal at breakfast time,\u201d the report says.<\/p>\n

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\u201cSince no pharmacokinetic studies of LSD have been conducted in dogs,\u201d authors explained, \u201cthe selected dose was extrapolated from human data, acknowledging potential interspecies differences in substance metabolism and effect.\u201d<\/p>\n

They added that no adverse effects were recorded over the course of treatment.<\/p>\n

Authors\u2014from the Universidad de Las Palmas de Gran Canaria and Asociaci\u00f3n Cient\u00edfica Psicod\u00e9lica, in the Canary Islands\u2014acknowledged that the study\u2019s \u201ckey limitation\u201d was its lack of a placebo-controlled, blinded design. The team nevertheless implemented \u201cmethodological precautions\u201d meant to reduce bias, they said, such as assessing anxiety through \u201cvalidated behavioural scales\u201d and evaluating both the owner\u2019s subjective observations as well as \u201cobjective indicators, such as vocalization duration and destructive behaviours.\u201d<\/p>\n

They also noted that the use of psychedelics in non-human animals could raise questions about informed consent and \u201cthe ability of animals to comprehend the nature and purpose of the study.\u201d<\/p>\n

\u201cWhile this study aimed to explore the potential therapeutic benefits of these substances, it is crucial to acknowledge the potential impact on animal welfare,\u201d they wrote. \u201cThe long-term effects of repeated psychedelic administration in animals are unknown, and further research is needed to assess potential adverse effects.\u201d<\/p>\n

Results of the new pilot study were nevertheless promising, the report<\/a> concludes.<\/p>\n

\u201cThe administration of 5 \u00b5g of 1cp-LSD once every 3 days over a 30-day period was associated with a reduction in severe anxiety to a moderate level in a female dog, with the effect persisting for 1 month posttreatment,\u201d it says, adding, however, that \u201cGiven the exploratory nature of this single-case study, these findings should be interpreted with caution.\u201d<\/p>\n

While the team\u2019s focus on LSD\u00a0is novel in a variety of ways, there\u2019s been growing interest within the scientific community about potential treatment alternatives for pets and other animals, including with cannabis.<\/p>\n

For example, the National Animal Supplement Council (NASC) promoted a study last year that it said shows CBD is \u201csafe for long-term use\u201d in dogs<\/a>\u2014a significant finding given emerging research that cannabis can effectively treat conditions such as anxiety and certain skin diseases among canines.<\/p>\n

Another 2024 case study found that cannabis appears to be a \u201cviable alternative\u201d treatment option for dogs<\/a>\u00a0suffering from a common skin disease, especially if they experience adverse side effects from conventional steroid therapies.<\/p>\n

A separate study late last year, meanwhile, found that giving dogs a dose of CBD could help counteract the ill effects of accidental THC consumption<\/a>.<\/p>\n

Authors of that report said reducing the cost of treating THC toxicosis is especially important given that cases of accidental marijuana exposure<\/a>\u00a0have been increasing in recent years and that the inability to afford emergency services is \u201ca leading barrier to accessing veterinary care in both the United States and Canada.\u201d<\/p>\n

Earlier this year, the U.S. Food and Drug Administration (FDA) sought input from veterinarians and the broader public about the use of cannabis-derived products\u2014in particular CBD\u2014in animals<\/a>. The agency wanted to know more about usage trends, potential drug interactions, quality standards and other issues related to the veterinary use of cannabinoids.<\/p>\n

The input is meant to help inform the Center for Veterinary Medicine\u2019s (CVM) \u201cknowledge of potential safety signals associated with these products, in addition to aiding our understanding of veterinarians\u2019 experiences related to the use of CDPs [cannabis-derived products] for their animal patients,\u201d the FDA filing said.<\/p>\n

\u201cFDA has made the regulation of the CBD market a priority, including products marketed for animals,\u201d it added. \u201cWhile there is some limited published information about use of CDPs in animals, significant data gaps exist surrounding many aspects of CBD and other CDPs in animals.\u201d<\/p>\n

Among other relevant research, a study published in early 2023 found that dogs that receive daily doses of CBD see \u201csignificant reductions\u201d in stress and anxiety<\/a>\u00a0related to car travel.<\/p>\n

Other studies have demonstrated benefits of CBD such as\u00a0reduced frequency of seizures among dogs who receive the cannabinoid<\/a>, while a study published in 2018 found that CBD treatment appeared to improve canine arthritis<\/a>.<\/p>\n

Last August, the U.S. Department of Agriculture (USDA) found that\u00a0cows that are fed hempseed cake retain very low concentrations of THC and CBD<\/a>\u00a0in their bodies, indicating that meat products from hemp-fed cattle are safe for human consumption.<\/p>\n

Another federally funded study published in 2022 found that\u00a0feeding cows hemp reduces their stress<\/a>. Researchers have also looked into\u00a0how CBD affects stress and pain in horses<\/a>.<\/p>\n

Photo courtesy of Pexels<\/a>.<\/em><\/p>\n

The post Microdosing LSD Can Help Treat Separation Anxiety In Dogs, New Case Study Suggests<\/a> appeared first on Marijuana Moment<\/a>.<\/p>\n


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\nRead More: Microdosing LSD Can Help Treat Separation Anxiety In Dogs, New Case Study Suggests<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A new case study in the journal Veterinary Medicine and Science suggests that very small doses of the psychedelic LSD appeared to ease a dog\u2019s severe separation anxiety, reducing destructive behavior and shortening the duration of vocalizations. Authors of the report said the results \u201csuggest potential therapeutic efficacy of microdosingContinue Reading<\/a><\/span><\/p>\n","protected":false},"author":24,"featured_media":0,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[18,15462,126],"tags":[],"_links":{"self":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/82640"}],"collection":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/comments?post=82640"}],"version-history":[{"count":1,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/82640\/revisions"}],"predecessor-version":[{"id":82641,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/82640\/revisions\/82641"}],"wp:attachment":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/media?parent=82640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/categories?post=82640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/tags?post=82640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}