A new federal funding opportunity from the National Institutes of Health (NIH) will use $8.4 million to support clinical trials on the safety and efficacy of psychedelic-assisted therapy to treat chronic pain in older adults.<\/p>\n
An NIH notice of funding opportunity posted on Wednesday says the research can include \u201cclassic\u201d psychedelics\u2014including psilocybin, DMT, LSD and mescaline\u2014as well as similar compounds such as MDMA. Cannabis and ketamine are not considered psychedelics for the purposes of the clinical trials.<\/p>\n
\u201cApproximately 40% of older Americans report living with chronic pain,\u201d the funding notice says, with treatment of pain later in life\u2014involving acetaminophen, NSAIDs, opioids and other drugs, along with behavioral therapy, physical activity, acupuncture and electrical stimulation\u2014 being \u201ccomplex and often inadequate.\u201d<\/p>\n
\u201cA potential novel approach to treatment of chronic pain in adults involves psychedelic-assisted therapy (PAT),\u201d it continues. \u201cResearch with psychedelics was inspired by millennia of Indigenous experience incorporating sacred plant medicines in ceremonial healing practices.\u201d<\/p>\n
More recently, the notice says, \u201cEvidence for the efficacy of PAT has been particularly notable in depression, anxiety (especially existential distress), post-traumatic stress disorder (PTSD), and substance use disorders, among other indications.\u201d<\/p>\n
The grant, which will be overseen by NIH component agencies the National Institute on Aging (NIA) and the National Center for Complementary and Integrative Health (NCCIH), will award up to $3.4 million per year in fiscal 2025\u20132026 and up to $5 million per year in fiscal 2027\u20132029. The broad range of eligible organizations includes colleges and universities, nonprofits, for-profit businesses, state or local governments, federal agencies and others, such as school districts or tribal organizations.<\/p>\n
\nSafety and Early Efficacy Studies of Psychedelic-Assisted Therapy for Chronic Pain in Older Adults (UG3\/UH3 Clinical Trial Required) https:\/\/t.co\/QQJ84LcfkJ<\/a><\/p>\n
\u2014 NIH Funding (@NIHFunding) April 24, 2024<\/a><\/p>\n<\/blockquote>\n\n
The new funding is aimed at supporting a \u201cclinical trials network involving multiple institutions collecting safety and early efficacy data\u201d among older people with chronic pain.<\/p>\n
\u201cThe first phase will involve safety and efficacy study in older adults, and the second phase will involve expanded safety and efficacy studies in older adults with chronic pain conditions,\u201d the NIH posting<\/a> says. \u201cThis funding structure is expected to lead to a higher level of collaboration, planning, and harmonization than would be possible through multiple individually funded grants.\u201d<\/p>\n
The federal agency notes that while \u201cprevious studies of PAT have included limited numbers of older adults who have tolerated treatment well without significant adverse effects, more focused safety and efficacy studies in older adults are needed.\u201d<\/p>\n
Applications for the new grant money can be submitted as of September 10. The application window will close a month later, on October 10. The earliest start date for the work is set for July 2025.<\/p>\n
Recently, a separate study published by the American Medical Association found that single-dose psilocybin use was \u201cnot associated with risk of paranoia,\u201d<\/a> while other adverse effects such as headaches are generally \u201ctolerable and resolved within 48 hours.\u201d<\/p>\n
That study, published in JAMA Psychiatry earlier this month, involved a meta-analysis of double-blind clinical trials where psilocybin was used to treat anxiety and depression from 1966 to last year.<\/p>\n
AMA published a separate study last month that similarly contradicted commonly held beliefs about the potential risks of psychedelics use, finding the substances\u00a0\u201cmay be associated with lower rates of psychotic symptoms among adolescents.\u201d<\/a><\/p>\n
Also, result of a clinical trial published by AMA in December\u00a0\u201csuggest efficacy and safety\u201d of psilocybin-assisted psychotherapy<\/a>\u00a0for treatment of bipolar II disorder, a mental health condition often associated with debilitating and difficult-to-treat depressive episodes.<\/p>\n
The association also published research last August that found people with major depression experienced\u00a0\u201cclinically significant sustained reduction\u201d in their symptoms<\/a>\u00a0after just one dose of psilocybin.<\/p>\n
Another recent study suggests that the use of full-spectrum psychedelic mushroom extract\u00a0has a more powerful effect than chemically synthesized psilocybin alone<\/a>, which could have implications for psychedelic-assisted therapy. The findings imply that the experience of entheogenic mushrooms may involve a so-called \u201centourage effect\u201d\u00a0similar to what\u2019s observed with cannabis and its many components.<\/a><\/p>\n
\n\u2018No Evidence\u2019 That Marijuana Legalization For Adults Increases Youth Cannabis Use, New Research Published By American Medical Association Finds<\/a><\/p>\n<\/blockquote>\n\n
Photo courtesy of Wikimedia\/Workman<\/a>.<\/em><\/p>\n
The post Feds Announce Plan To Fund Research On Using Psychedelics To Treat Chronic Pain In Older Adults<\/a> appeared first on Marijuana Moment<\/a>.<\/p>\n
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\nRead More: Feds Announce Plan To Fund Research On Using Psychedelics To Treat Chronic Pain In Older Adults<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"A new federal funding opportunity from the National Institutes of Health (NIH) will use $8.4 million to support clinical trials on the safety and efficacy of psychedelic-assisted therapy to treat chronic pain in older adults. An NIH notice of funding opportunity posted on Wednesday says the research can include \u201cclassic\u201dContinue Reading<\/a><\/span><\/p>\n","protected":false},"author":24,"featured_media":0,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[18,15462],"tags":[],"_links":{"self":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/74743"}],"collection":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/comments?post=74743"}],"version-history":[{"count":1,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/74743\/revisions"}],"predecessor-version":[{"id":74744,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/74743\/revisions\/74744"}],"wp:attachment":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/media?parent=74743"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/categories?post=74743"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/tags?post=74743"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}