A new study published in the Journal of the American Medical Association (JAMA) Psychology looked at pairs of twins in an effort to untangle the relationship between psychedelic use and psychotic or manic symptoms in young people, concluding\u2014contrary to popular fears\u2014that use of psychedelics \u201cmay be associated with lower rates of psychotic symptoms among adolescents.\u201d<\/p>\n
Manic symptoms, meanwhile, were linked to psychedelic use, but that appeared to be due to genetic predisposition.<\/p>\n
\u201cPsychedelic use was associated with more manic symptoms for individuals with a higher genetic vulnerability to schizophrenia or bipolar I disorder than in individuals with a lower genetic vulnerability,\u201d researchers wrote, \u201cwhich provides tentative evidence in support of contemporary guidelines on psychedelic research.\u201d<\/p>\n
Virtually all current psychedelic research\u2014including leading clinical trials\u2014excludes people with a genetic vulnerability to psychotic or bipolar disorders, the authors noted, though \u201cthere is a lack of consensus on the risks associated with psychedelic use for these populations, especially among adolescents.\u201d<\/p>\n
The report describes a cross-sectional study of adolescent twins in Sweden using data from a national registry. Participants were asked about their past use of various drugs at age 15 as well as symptoms of psychosis and mania. Supplementary analyses looked at parent-reported observations and other self-reported data.<\/p>\n
\n\u201cPsychedelic use was significantly associated with lower rates of psychotic symptoms when adjusting for other drug use.\u201d<\/p>\n<\/blockquote>\n
\u201cWhen adjusting for substance-specific and substance-aggregated drug use, psychedelic use was associated with fewer psychotic symptoms in both linear regression analyses and co-twin control analyses,\u201d the study found. \u201cIn individuals with a higher genetic vulnerability to schizophrenia or bipolar I disorder, psychedelic use was associated with more manic symptoms than in individuals with a lower genetic vulnerability.\u201d<\/p>\n
\u201cTaken together,\u201d it says, \u201cthe findings in this study suggest that, after adjusting for other drug use, naturalistic use of psychedelics may be associated with lower rates of psychotic symptoms among adolescents. At the same time, the association between psychedelic use and manic symptoms seems to depend on genetic vulnerability to psychopathology such as schizophrenia or bipolar I disorder.\u201d<\/p>\n
The associations, researcher warn, \u201cshould be interpreted with caution,\u201d noting limitations such as missing data in survey responses, the possibility of underreporting symptoms in self-reported surveys, a lack of information about the context of past psychedelic use, potential trouble interpreting research questions and various biases among respondents.<\/p>\n
Nevertheless, they noted, \u201cthe use of co-twin control studies represents a novel research design in psychedelic research that can further inform associations and may be particularly useful when it is not feasible to conduct an experimental study.\u201d<\/p>\n
\u201cTaken together, this study has advantages as a population-based naturalistic study that takes genetics into account, but the findings in this study should be interpreted with caution until they have been replicated in future studies,\u201d the report<\/a> says.<\/p>\n
The findings come on the heels of another article published by the American Medical Association this week concluding that the use of the broadly unregulated cannabinoid delta-8 THC<\/a> was higher among high-school seniors in states where marijuana remained illegal, as well as in states that had not adopted regulations around hemp-derived cannabinoids.<\/p>\n
Last year, a separate study of young people at risk of developing psychotic disorders found that regular marijuana use over a two-year period did not trigger early onset of symptoms<\/a>. In fact, it was associated with modest improvements in cognitive functioning and reduced use of other medications\u2014a finding that researchers themselves called surprising.<\/p>\n
An earlier JAMA-published study that looked at data from more than 63 million health insurance beneficiaries, meanwhile, found that there\u2019s \u201cno statistically significant increase\u201d in psychosis-related diagnoses<\/a> in states that have legalized marijuana compared to those that continue to criminalize cannabis.<\/p>\n
\nFears About Marijuana And Psychosis Need To Be Placed In Scientific Context, Not Hyped Up By The Media (Op-Ed)<\/a><\/p>\n<\/blockquote>\n\n
The post Psychedelic Use Linked To \u2018Lower Rates Of Psychotic Symptoms\u2019 In Adolescents, Study Published By American Medical Association Finds<\/a> appeared first on Marijuana Moment<\/a>.<\/p>\n
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\nRead More: Psychedelic Use Linked To \u2018Lower Rates Of Psychotic Symptoms\u2019 In Adolescents, Study Published By American Medical Association Finds<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"A new study published in the Journal of the American Medical Association (JAMA) Psychology looked at pairs of twins in an effort to untangle the relationship between psychedelic use and psychotic or manic symptoms in young people, concluding\u2014contrary to popular fears\u2014that use of psychedelics \u201cmay be associated with lower ratesContinue Reading<\/a><\/span><\/p>\n","protected":false},"author":24,"featured_media":0,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[18,15462],"tags":[],"_links":{"self":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/73194"}],"collection":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/users\/24"}],"replies":[{"embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/comments?post=73194"}],"version-history":[{"count":1,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/73194\/revisions"}],"predecessor-version":[{"id":73195,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/73194\/revisions\/73195"}],"wp:attachment":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/media?parent=73194"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/categories?post=73194"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/tags?post=73194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}