A top federal health agency announced on Friday that it has determined the standard dose of THC that should be used for marijuana studies moving forward.<\/p>\n
The National Institute on Drug Abuse (NIDA) said in a notice to researchers that there is a \u201cnew requirement to measure and report results using a standard THC unit in all applicable human subjects\u2019 research,\u201d which is effective immediately. That standard unit is five milligrams of THC.<\/p>\n
NIDA said that inconsistencies in measuring and reporting THC exposure \u201chas been a major limitation in studies of cannabis use, making it difficult to compare findings among studies.\u201d Therefore, a \u201cstandardized measure of THC in cannabis products is necessary to advance research by providing greater comparability across studies of both its adverse effects and potential medical uses.\u201d<\/p>\n
The agency recognized, however, that \u201cthe same quantity of THC may have different effects based on route of administration, other product constituents, an individual\u2019s genetic make-up and metabolic factors, prior exposure to cannabis, and other factors.\u201d<\/p>\n
But by creating a standard THC dose, it will nonetheless be easier to compare studies that involve THC exposure, which is a \u201chigh priority\u201d of NIDA and the National Advisory Council on Drug Abuse.<\/p>\n
\u201cIt is not the intent of this Notice to prescribe the quantity of THC that is permissible for use in research projects. Indeed, investigators are free to use more or less than 5mg of THC as appropriate for their study,\u201d the notice states<\/a>. \u201cHowever, for applicable studies, investigators will be required to report the quantity of THC using the standard unit. Investigators may also report the quantity of THC in other units (e.g., milligrams) as appropriate.\u201d<\/p>\n This comes one year after NIDA, which is part of the National Institutes of Health, first solicited feedback on a proposal to standardize THC content<\/a> in cannabis research.<\/p>\n The agency said that it carried out \u201cextensive stakeholder input,\u201d along with \u201cconsultation with experts in the field,\u201d to arrive at the decision to set the standard unit at 5 mg.<\/p>\n \u201cThis guidance will apply to applications where THC is a focus of the research,\u201d the new notice continues. \u201cApplicants are responsible for determining whether use of this standard unit is applicable to their research and for determining best approach to applying it in their research applications. A justification should be provided for research that does not propose to use the standard unit.\u201d<\/p>\n NIDA Director Nora Volkow discussed the importance of establishing a standard THC unit in commentary published in the journal Addiction last year.<\/p>\n Citing research that calls for a five milligram THC standard, Volkow\u00a0said<\/a>\u00a0she agreed with the study\u2019s conclusion despite complicating factors. Those factors include potential issues related to the effect of having cannabis products with the same THC level but different concentrations of other cannabinoids such as CBD.<\/p>\n The complexities in research beyond having a standardized measure of THC \u201chardly negate the value\u201d of setting one, Volkow said in her commentary. \u201cIn fact, having and using such a standard is a prerequisite for comparing the effects of various cannabis products on THC bioavailability, pharmacokinetics and pharmacological effects, which is knowledge fundamental to studies pertaining to medical use of cannabis.\u201d<\/p>\n \u201cAlthough cannabis remains an illicit substance in the United States, the expanded legalization by states requires us to develop the knowledge base that can help states develop policies to minimize risk from cannabis exposures, such as limits on the THC content of cannabis products,\u201d she said.<\/p>\n Volkow has been\u00a0vocal about the importance of streamlining and improving research into cannabis<\/a>, and she\u2019s\u00a0laid partial blame for the the lack of studies on marijuana\u2019s restrictive federal classification<\/a>.<\/p>\n Kansas Senate Running Out Of Time To Pass Medical Marijuana Legalization Bill That Cleared House<\/a><\/p>\n<\/blockquote>\n\n The post Feds Announce New Standard THC Dose To Be Used In Marijuana Research, Effective Immediately<\/a> appeared first on Marijuana Moment<\/a>.<\/p>\n
A top federal health agency announced on Friday that it has determined the standard dose of THC that should be used for marijuana studies moving forward. The National Institute on Drug Abuse (NIDA) said in a notice to researchers that there is a \u201cnew requirement to measure and report resultsContinue Reading<\/a><\/span><\/p>\n","protected":false},"author":458,"featured_media":0,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[18,81],"tags":[],"_links":{"self":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/47577"}],"collection":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/users\/458"}],"replies":[{"embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/comments?post=47577"}],"version-history":[{"count":1,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/47577\/revisions"}],"predecessor-version":[{"id":47578,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/47577\/revisions\/47578"}],"wp:attachment":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/media?parent=47577"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/categories?post=47577"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/tags?post=47577"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
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\nRead More: Feds Announce New Standard THC Dose To Be Used In Marijuana Research, Effective Immediately<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"