Super-strength cannabis edibles have a small but passionate legion of defenders. In certain cases, for instance, there is a wholly valid medical justification for a 1000-milligram brownie \u2014 but the truth is, marijuana-laced goodies are not for everyone.\u00a0<\/p>\n
And this is particularly true at high doses.<\/p>\n
Whenever \u201cextreme adverse effects\u201d result from cannabis, it seems an edible (or a plateful of them) is involved. This is why most states with legalized adult-use cannabis have passed laws limiting the amount of\u00a0THC<\/a>\u00a0in edibles, and why these limits haven\u2019t been overturned.<\/p>\n It turns out preferring a mild buzz to a days-long, edible-triggered, near-psychedelic odyssey may be wired into our brains. Because as researchers at Indiana University and Purdue University recently found, this preference appears to be\u00a0absolutely<\/em>\u00a0wired into the brains of mice.<\/p>\n In a study, results of which were\u00a0published<\/a>\u00a0in the journal\u00a0Drug and Alcohol Dependence, researchers at\u00a0the\u00a0Department of Psychology and Indiana Alcohol Research Center, Indiana University \u2013 Purdue University\u00a0in Indianapolis fed a cohort of mice dough infused with THC, in variable amounts.\u00a0<\/p>\n Doses in the dough\u00a0ranged from\u00a01 milligram of THC per kilogram of bodyweight\u00a0to up to\u00a010 milligrams of THC per kilogram.\u00a0The mice also had access to \u201cnormal\u201d food and water, which suggests they were not attacking the dough out of hunger. (For comparison\u2019s sake: a 180-pound man would be eating an edible with roughly 800 milligrams of THC were he to match the mightiest mouse dough.)<\/p>\n The mice ate the dough \u2014 as lab mice are wont to do \u2014 but the more powerful the dough, the less the mice ate, researchers found.\u00a0When the dough was at 5 mg\/kg or 10 mg\/kg,\u00a0some of the\u00a0mice ate \u201csignificantly less\u201d than 100%, suggesting there was something in that dough that disagreed with the mice.<\/p>\n \u201cThe simple fact that mice self-administered THC dough could be seen as evidence that it is rewarding,\u201d the researchers wrote. \u201cHowever, inspection of consumption patterns indicates that THC might have been aversive at higher dose.\u201d<\/p>\n But not every mouse shied away from the highest-strength dough. Some mice ate it all, no matter how strong. After eating the dough, effects included less movement and a decrease in body temperature \u2014 you know, typical stoned mice things. Interestingly, the impact was most pronounced in the male mice, the researchers found.<\/p>\n The study \u201cdemonstrated what appears to be THC-induced conditioned taste aversion,\u201d the researchers wrote, adding that the mice did not appear to be stressed and were otherwise perfectly fine, if very blazed.<\/p>\n The study is notable for a few reasons. There is limited scientific data on self-administration of THC, even among animals. And since there are still legal and \u201cethical\u201d barriers to performing such experiments on humans, as the researchers noted, mice \u2014 who, like rats, provide something of a yardstick<\/a> for understanding biology and functions like the immune system in humans \u2014 are the next-best option. And this study is one of few where an animal subject had access to self-administered THC at all, meaning it\u2019s one of the few where desire for THC could be gauged. <\/p>\n It\u2019s neither accurate nor fair to say that edibles are a liability. But among the problems that have arisen during the cannabis legalization era, powerful edibles \u2014 and eating too much of them \u2014 has absolutely been one of the marijuana movement\u2019s biggest challenges.<\/p>\n The good news is that edibles are relatively easy to manage, because this is what labeling is for. And if you are a human who prefers a\u00a0microdose<\/a>\u00a0to a heroic macro-brownie, just know that you are not alone in the animal kingdom.<\/p>\n TELL US<\/strong>, what\u2019s your perfect edibles dosage?<\/p>\n The post Study: Everyone Prefers Low-Dose Cannabis Edibles \u2014 Even Mice<\/a> appeared first on Cannabis Now<\/a>.<\/p>\n
Super-strength cannabis edibles have a small but passionate legion of defenders. In certain cases, for instance, there is a wholly valid medical justification for a 1000-milligram brownie \u2014 but the truth is, marijuana-laced goodies are not for everyone.\u00a0 And this is particularly true at high doses. Whenever \u201cextreme adverse effects\u201dContinue Reading<\/a><\/span><\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"false","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[50,111,9881,5077,7208,420],"tags":[],"_links":{"self":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/35010"}],"collection":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/comments?post=35010"}],"version-history":[{"count":1,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/35010\/revisions"}],"predecessor-version":[{"id":35011,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/posts\/35010\/revisions\/35011"}],"wp:attachment":[{"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/media?parent=35010"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/categories?post=35010"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cannabiscultivatornews.com\/home\/index.php\/wp-json\/wp\/v2\/tags?post=35010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Know Thy Limits<\/h4>\n
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\nRead More: Study: Everyone Prefers Low-Dose Cannabis Edibles \u2014 Even Mice<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"